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Article

Functional restoration of the Ca2+-myristoyl switch in a recoverin mutant.

Journal of molecular biology - 4 Jul 2003

Senin Ivan I, Vaganova Svetlana A, Weiergräber Oliver H, Ergorov Nikolay S, Philippov Pavel P, Koch Karl Wilhelm

Abstract excerpt

Recoverin is a neuronal calcium sensor protein that plays a crucial role in vertebrate phototransduction. It undergoes a Ca(2+)-myristoyl switch when Ca(2+) binds to its two functional EF-hand motifs (EF-hands 2 and 3), each present in one of recoverin's two domains. Impairment of Ca(2+)-binding...

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Source

Identifiers

PMID: 12823978
DOI: 10.1016/s0022-2836(03)00581-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12823978-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Functional restoration of the Ca2+-myristoyl switch in a recoverin mutant.PMID 12823978Read ↗

Structure and calcium-binding studies of a recoverin mutant (E85Q) in an allosteric intermediate state.Semantic proximity Read ↗

Obtaining and characterization of EF-hand mutants of recoverin.Semantic proximity Read ↗

Structure and membrane-targeting mechanism of retinal Ca2+-binding proteins, recoverin and GCAP-2.Semantic proximity Read ↗

A highly conserved cysteine of neuronal calcium-sensing proteins controls cooperative binding of Ca2+ to recoverin.Semantic proximity Read ↗

Effects of mutations in the calcium-binding sites of recoverin on its calcium affinity: evidence for successive filling of the calcium binding sites.Semantic proximity Read ↗

Recoverin binds exclusively to an amphipathic peptide at the N terminus of rhodopsin kinase, inhibiting rhodopsin phosphorylation without affecting catalytic activity of the kinase.Semantic proximity Read ↗

Calcium Sensing by Recoverin: Effect of Protein Conformation on Ion Affinity.Semantic proximity Read ↗

Recoverin is a zinc-binding protein.Semantic proximity Read ↗

Ca2+/recoverin dependent regulation of phosphorylation of the rhodopsin mutant R135L associated with retinitis pigmentosa.Semantic proximity Read ↗

Site-directed and natural mutations in studying functional domains in guanylyl cyclase activating proteins (GCAPs).Semantic proximity Read ↗

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