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Article

The role of dendritic cells in the pathogenesis of systemic lupus erythematosus

1 Jan 2010

Abstract excerpt

The etiology of the autoimmune disease systemic lupus erythematosus is not known, but aberrant apoptosis and/or insufficient clearance of apoptotic material have been assigned a pivotal role. During apoptosis, nucleosomes and several endogenous danger-associated molecular patterns are incorporated in blebs. Recent data indicate that apoptotic blebs induce maturation of myeloid dendritic cells, resulting in IL-17...

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PMID: 20423534
DOI: 10.1186/ar2966

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