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Article

In vivo measurements of changes in respiratory mechanics with age in mice deficient in surfactant protein D.

Pediatric research - 1 Mar 2003

Collins Rachel A, Ikegami Machiko, Korfhagen Thomas R, Whitsett Jeffrey A, Sly Peter D

Abstract excerpt

Mice deficient in surfactant protein D [SP-D (-/-)] develop progressive emphysema with age, associated with loss of parenchymal tissue, subpleural fibrosis, and accumulation of abnormal elastin fibers. We measured the changes in lung function, partitioned into components for the airways and lung parenchyma, occurring with age in SP-D (-/-) mice at three ages (n = 8 per group) (5, 8, and 13 wk). Impedance spectra...

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Identifiers

PMID: 12595595
DOI: 10.1203/01.PDR.0000049464.46191.BF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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