Article
Altered surfactant function and structure in SP-A gene targeted mice.
Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 1996
Korfhagen T R, Bruno M D, Ross G F, Huelsman K M, Ikegami M, Jobe A H, Wert S E, Stripp B R, Morris R E, Glasser S W, Bachurski C J, Iwamoto H S, Whitsett J A
Abstract excerpt
The surfactant protein A (SP-A) gene was disrupted by homologous recombination in embryonic stem cells that were used to generate homozygous SP-A-deficient mice. SP-A mRNA and protein were not detectable in the lungs of SP-A(-/-) mice, and perinatal survival of SP-A(-/-) mice was not altered compared with wild-type mice. Lung morphology, surfactant proteins B-D, lung tissue, alveolar phospholipid pool sizes and...
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