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Article

Respiratory defects in the CrtapKO mouse model of osteogenesis imperfecta.

American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2020

Dimori Milena, Heard-Lipsmeyer Melissa E, Byrum Stephanie D, Mackintosh Samuel G, Kurten Richard C, Carroll John L, Morello Roy

Abstract excerpt

Respiratory disease is a leading cause of mortality in patients with osteogenesis imperfecta (OI), a connective tissue disease that causes severely reduced bone mass and is most commonly caused by dominant mutations in type I collagen genes. Previous studies proposed that impaired respiratory function in OI patients was secondary to skeletal deformities; however, recent evidence suggests the existence of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32022592
DOI: 10.1152/ajplung.00313.2019
PMCID: PMC7191481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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