Article
Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998
Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J, Clements J, Carlson E, Gillespie A M, Epstein C, Hawgood S
Abstract excerpt
Surfactant protein D (SP-D) is one of two collectins found in the pulmonary alveolus. On the basis of homology with other collectins, potential functions for SP-D include roles in innate immunity and surfactant metabolism. The SP-D gene was disrupted in embryonic stem cells by homologous recombin...
Topics
- Animals
- Bronchoalveolar Lavage Fluid
- Glycoproteins
- Homeostasis
- Hyperplasia
- Macrophages, Alveolar
- Mice
- Mice, Knockout
- Microscopy, Electron
- Phenotype
- Phospholipids
- Pulmonary Alveoli
- Pulmonary Surfactant-Associated Protein D
- Pulmonary Surfactants