Article
Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998
Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J, Clements J, Carlson E, Gillespie A M, Epstein C, Hawgood S
Abstract excerpt
Surfactant protein D (SP-D) is one of two collectins found in the pulmonary alveolus. On the basis of homology with other collectins, potential functions for SP-D include roles in innate immunity and surfactant metabolism. The SP-D gene was disrupted in embryonic stem cells by homologous recombination to generate mice deficient in SP-D. Mice heterozygous for the mutant SP-D allele had SP-D concentrations that...
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