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Article

Three Alveolar Phenotypes Govern Lung Function in Murine Ventilator-Induced Lung Injury

30 Jun 2020

Abstract excerpt

Mechanical ventilation is an essential lifesaving therapy in acute respiratory distress syndrome (ARDS) that may cause ventilator induced lung injury (VILI) through a positive feedback between altered alveolar mechanics, edema, surfactant inactivation, and injury. Although the biophysical forces that cause VILI are well documented, a knowledge gap remains in the quantitative link between altered parenchymal...

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PMID: 32695013
DOI: 10.3389/fphys.2020.00660

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