Article
De novo production of diverse intracellular antibody libraries.
Nucleic acids research - 1 Mar 2003
Tanaka Tomoyuki, Chung Grace T Y, Forster Alan, Lobato M Natividad, Rabbitts Terence H
Abstract excerpt
Many therapeutic targets are intracellular proteins and molecules designed to interact with them must effectively bind to their target inside the cell. Intracellular antibodies (intrabodies) recognise and bind to proteins in cells and various methods have been developed to produce such molecules. Intracellular antibody capture (IAC) is based on a genetic screening approach and is a facile methodology with which...
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