Article

Intracellular targeting with engineered proteins

2016-08-10

Abstract excerpt

If the isolation, production, and clinical use of insulin marked the inception of the age of biologics as therapeutics, the convergence of molecular biology and combinatorial engineering techniques marked its coming of age. The first wave of recombinant protein-based drugs in the 1980s demonstrated emphatically that proteins could be engineered, formulated, and employed for clinical advantage. Yet despite the succ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c11d74c-3ba7-5ca9-bfc4-519d868a4c06
DOI: 10.12688/f1000research.8915.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intracellular targeting with engineered proteinsDOI 10.12688/f1000research.8915.1Read

Modular Protein Engineering in Emerging Cancer TherapiesSemantic proximity Read

Intracellular antibodies and cancer: New technologies offer therapeutic opportunitiesSemantic proximity Read

Protease-Containing Nanobodies for Detecting and Manipulating Intracellular Antigens Using Antiviral DrugsSemantic proximity Read

Engineering Cell-Permeable Proteins through Insertion of Cell-Penetrating Motifs into Surface Loops.Semantic proximity Read

Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and OncologySemantic proximity Read

Affinity‐Directed Site‐Specific Protein Labeling and Its Application to Antibody‐Drug ConjugatesSemantic proximity Read

Reliable repurposing of antibody interactome inside the cellSemantic proximity Read

INTRACELLULAR ANTIBODIES (INTRABODIES) FOR GENE THERAPY OF INFECTIOUS DISEASESSemantic proximity Read

Recombinant proteins for therapySemantic proximity Read

Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disordersSemantic proximity Read

Engineering of extracellular vesicles for display of protein biotherapeuticsSemantic proximity Read

Intrabody-based approaches to cancer therapy: status and prospects.Semantic proximity Read