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Intracellular antibodies and cancer: New technologies offer therapeutic opportunities

11 Jun 2010

Abstract excerpt

Since the realisation that the antigen-binding regions of antibodies, the variable (V) regions, can be uncoupled from the rest of the molecule to create fragments that recognise and abrogate particular protein functions in cells, the use of antibody fragments inside cells has become an important tool in bioscience. Diverse libraries of antibody fragments plus in vivo screening can be used to isolate single chain...

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PMID: 20544739
DOI: 10.1002/bies.201000009

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