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Article

Surrogate molecular markers for IGHV mutational status in chronic lymphocytic leukemia for predicting time to first treatment.

Leukemia research - 1 Aug 2015

Morabito Fortunato, Cutrona Giovanna, Mosca Laura, D'Anca Marianna, Matis Serena, Gentile Massimo, Vigna Ernesto, Colombo Monica, Recchia Anna Grazia, Bossio Sabrina, De Stefano Laura, Maura Francesco, Manzoni Martina, Ilariucci Fiorella, Consoli Ugo, Vincelli Iolanda, Musolino Caterina, Cortelezzi Agostino, Molica Stefano, Ferrarini Manlio, Neri Antonino

Abstract excerpt

ZAP-70 is a marker of clinical outcome in chronic lymphocytic leukemia (CLL), however its assessment suffers from a lack of standardization consensus. To identify novel markers able to surrogate IGHV mutational status, CD19(+)CD5(+)-B-lymphocytes from 216 patients enrolled in a prospective study (ClinicalTrial.gov Identifier:NCT00917540), underwent gene expression profiling. Samples were split into CLL-Training...

Topics

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Disease Progression
Follow-Up Studies
Genes, Immunoglobulin Heavy Chain
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Lymphocytic, Chronic, B-Cell

Predictive Value of Tests

ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 26038121
DOI: 10.1016/j.leukres.2015.05.005

Genes

CRY1
MBOAT1
LPL
NRIP1
TGFBR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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