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Article

Identification and Functional Characterization of a New Gene Encoding the Mouse Terminal Complement Inhibitor CD59

1 Sept 2000

Abstract excerpt

CD59 is a 18- to 20-kDa, GPI-anchored membrane protein that functions as a key regulator of the terminal step of the complement activation cascade. It restricts binding of C9 to the C5b-8 complex, thereby preventing the formation of the membrane attack complex (C5b-9 of complement). A single human CD59 gene has been identified, and corresponding genetic homologues from rat, mouse, and pig have been characterized...

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Identifiers

PMID: 10946279
DOI: 10.4049/jimmunol.165.5.2528

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