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Article

Generation and phenotyping of mCd59a and mCd59b double-knockout mice.

American journal of hematology - 1 Feb 2009

Qin Xuebin, Hu Weiguo, Song Wenping, Grubissich Luciano, Hu Xuemei, Wu Gongxiong, Ferris Sean, Dobarro Martin, Halperin Jose A

Abstract excerpt

CD59 is a membrane protein inhibitor of the membrane attack complex (MAC) of complement. Humans express only one, whereas mice express two CD59 genes. We previously reported the targeted deletion of the mCd59b gene in which absence of mCd59b together with an unintended down regulation of mCd59a caused hemolytic anemia with spontaneous platelet activation. To confirm the complement role in the hemolytic anemia...

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Share to Anemia, Hemolytic, Congenital
Share to CD59 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Artificial, Bacterial

Share to Complement C3

Share to Fluorescent Antibody Technique, Indirect

Share to Gene Knockout Techniques

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Source

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Identifiers

PMID: 19051264
DOI: 10.1002/ajh.21319
PMCID: PMC4280255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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