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Article

Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex.

Circulation research - 27 Feb 2009

Wu Gongxiong, Hu Weiguo, Shahsafaei Aliakbar, Song Wenping, Dobarro Martin, Sukhova Galina K, Bronson Rod R, Shi Guo-Ping, Rother Russell P, Halperin Jose A, Qin Xuebin

Abstract excerpt

Complement is a central effector system within the immune system and is implicated in a range of inflammatory disorders. CD59 is a key regulator of complement membrane attack complex (MAC) assembly. The atherogenic role of terminal complement has long been suspected but is still unclear. Here, we demonstrate that among mice deficient in apolipoprotein (Apo)E, the additional loss of murine CD59...

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Identifiers

PMID: 19131645
DOI: 10.1161/CIRCRESAHA.108.191361
PMCID: PMC4267695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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