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Article

Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in mice.

Bone - 1 Mar 2016

Bloom Anja C, Collins Fraser L, Van't Hof Rob J, Ryan Elizabeth S, Jones Emma, Hughes Timothy R, Morgan B Paul, Erlandsson Malin, Bokarewa Maria, Aeschlimann Daniel, Evans Bronwen A J, Williams Anwen S

Abstract excerpt

Degenerative joint diseases such as osteoarthritis are characterised by aberrant region-specific bone formation and abnormal bone mineral content. A recent study suggested a role for the complement membrane attack complex in experimental models of osteoarthritis. Since CD59a is the principal regulator of the membrane attack complex in mice, we evaluated the impact of CD59a gene deletion upon maintenance of bone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26721735
DOI: 10.1016/j.bone.2015.12.014
PMCID: PMC4764651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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