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Article

Association of Blood Group Antigen CD59 with Disease

1 Jan 2022

Abstract excerpt

In 2014, the membrane-bound protein CD59 became a blood group antigen. CD59 has been known for decades as an inhibitor of the complement system, located on erythrocytes and on many other cell types. In paroxysmal nocturnal haemoglobinuria (PNH), a stem cell clone with acquired deficiency to express GPI-anchored molecules, including the complement inhibitor CD59, causes severe and life-threatening disease. The...

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PMID: 35221864
DOI: 10.1159/000521174

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