Article
Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1.
Oncogene - 20 Feb 2003
Plymate Stephen R, Haugk Kathy H, Sprenger Cynthia C, Nelson Peter S, Tennant Marie K, Zhang Yuping, Oberley Larry W, Zhong Weixiong, Drivdahl Rolf, Oberley Terry D
Abstract excerpt
Increased expression of mac25/insulin-like growth factor binding-protein related protein-1 (IGFBP-rP1) in human breast and prostate epithelial cell lines results in the suppression of tumor growth. CDNA expression array analysis revealed increased manganese superoxide dismutase (SOD-2) expression in the mac25/IGFBP-rP1-transfected M12 human prostate cancer cell line compared to M12 control cells. SOD-2 has been...
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