Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers.

British journal of cancer - 24 Feb 2003

Shono Y, Tanimura H, Iwahashi M, Tsunoda T, Tani M, Tanaka H, Matsuda K, Yamaue H

Abstract excerpt

Mutations of codon 12 in the Ki-ras gene are frequently found in pancreatic and colorectal cancers. It has been demonstrated that human T-cells have the potential to recognise tumours expressing mutated ras-derived peptides. However, it remains unclear whether T-cells from a given individual can recognise the mutant peptides, which are expressed in that individual's tumour tissues. Mutations of the Ki-ras...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HLA-DQ Antigens
Share to HLA-DR Antigens
Share to Interferon-gamma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 12592366
DOI: 10.1038/sj.bjc.6600697
PMCID: PMC2377177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers.PMID 12592366Read ↗

Naturally occurring T-cell response against mutated p21 ras oncoprotein in pancreatic cancer.Semantic proximity Read ↗

Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation.Semantic proximity Read ↗

Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12Val) peptide vaccination of a patient, recognize 12Val-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation.Semantic proximity Read ↗

Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors.Semantic proximity Read ↗

Targeting mutated K-ras in pancreatic adenocarcinoma using an adjuvant vaccine.Semantic proximity Read ↗

Pilot study of mutant ras peptide-based vaccine as an adjuvant treatment in pancreatic and colorectal cancers.Semantic proximity Read ↗

[Specific immune against pancreatic cancer induced by dendritic cells pulsed with mutant K-ras peptide].Semantic proximity Read ↗

HLA-A3 restricted mutant ras specific cytotoxic T-lymphocytes induced by vaccination with T-helper epitopes.Semantic proximity Read ↗

p21-ras-peptide-specific T-cell responses in a patient with colorectal cancer. CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation (13Gly-->Asp).Semantic proximity Read ↗

Induction in transgenic mice of HLA-A2.1-restricted cytotoxic T cells specific for a peptide sequence from a mutated p21ras protein.Semantic proximity Read ↗

Detection of Ki-ras mutations in tissue and plasma samples of patients with pancreatic cancer using PNA-mediated PCR clamping and hybridisation probesSemantic proximity Read ↗

Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.