Article
Targeting mutated K-ras in pancreatic adenocarcinoma using an adjuvant vaccine.
American journal of clinical oncology - 1 Jun 2011
Abou-Alfa Ghassan K, Chapman Paul B, Feilchenfeldt Jonas, Brennan Murray F, Capanu Marinela, Gansukh Bolorsukh, Jacobs Gria, Levin Adrah, Neville Deirdre, Kelsen David P, O'Reilly Eileen M
Abstract excerpt
PURPOSE: Codon 12 mutations of K-ras are frequent in pancreatic adenocarcinoma, and represent potential tumor-specific neoantigens. The objective of this study was to assess the safety and efficacy of immunizing patients with resected pancreatic cancer with a vaccine targeted against their tumor-specific K-ras mutation. METHODS: Patients with resected pancreatic cancer, with K-ras mutations at codon 12, were...
Topics
- Adenocarcinoma
- Adult
- Aged
- Cancer Vaccines
- Confounding Factors, Epidemiologic
- Drug Administration Schedule
- Enzyme-Linked Immunospot Assay
- Feasibility Studies
- Female
- Genes, ras
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans