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Article

K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke.

Experimental lung research - 1 Mar 2005

Yao Ruisheng, Wang Yian, D'Agostini Francesco, Izzotti Alberto, Lubet Ronald A, You Ming, De Flora Silvio

Abstract excerpt

In this study, we used p53 transgenic mice to investigate whether mice carrying this germline mutation would be susceptible to tobacco smoke-induced lung tumorigenesis. We subjected male transgenic mice and their wild-type littermates to whole-body exposure to environmental cigarette smoke (ECS) for up to 9.5 months. K-ras gene expression was significantly increased, 28 days after ECS exposure, in the apparently...

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Identifiers

PMID: 15824025
DOI: 10.1080/0190214059090386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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