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Article

Emerging role of alternative splicing of CRF1 receptor in CRF signaling.

16 Mar 2010

Abstract excerpt

Alternative splicing of mRNA is one of the most important mechanisms responsible for an increase of the genomic capacity. Thus the majority of human proteins including G protein-coupled receptors (GPCRs) possess several isoforms as a result of mRNA splicing. The corticotropin-releasing factor (CRF) and its receptors are the most proximal elements of hypothalamic-pituitary-adrenal axis (HPA) - the central...

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PMID: 20234885
DOI: 10.18388/abp.2010_2366

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