Article
Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles.
Cardiovascular research - 1 Nov 2005
Liao Ping, Yong Tan Fong, Liang Mui Cheng, Yue David T, Soong Tuck Wah
Abstract excerpt
An estimate of up to 60% of genes are subjected to alternative splicing, and 15% of human genetic diseases are associated with mutation of the splice sites [Krawczak M, Reiss J, and Cooper DN. The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: causes and consequences. Hum Genet 1992; 90: 41-54; Cooper TA, and Mattox W. The regulation of splice-site selection, and...
Topics
- Alternative Splicing
- Animals
- Calcium Channels, L-Type
- Cardiovascular Diseases
- Humans
- Muscle, Smooth
- Mutation
- Myocardium