Direct isolation of longevity mutants in the nematode Caenorhabditis elegans.

doi:10.1002/(SICI)1520-6408(1996)18:2<144::AID-DVG7>3.0.CO;2-9

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Article

Direct isolation of longevity mutants in the nematode Caenorhabditis elegans.

Developmental genetics - 1 Jan 1996

Duhon S A, Murakami S, Johnson T E

Abstract excerpt

We have isolated several new EMS-induced, long-lived mutants of Caenorhabditis elegans, using a novel screen that eliminates the need for replica plating. Three new alleles of age-1 (z10, z12, and z25) were identified by failure to complement age-1 (hx546) for life span extension; these alleles had life spans ranging from 18.9 to 25.9 days at 25 degrees C, with an average 46% increase in life span. After...

Topics

Animals
Caenorhabditis elegans
Fertility
Genetic Complementation Test
Hot Temperature
Longevity
Mutation
Reactive Oxygen Species
Ultraviolet Rays

Source

Open in PubMed

Identifiers

PMID: 8934876
DOI: 10.1002/(SICI)1520-6408(1996)18:2<144::AID-DVG7>3.0.CO;2-9

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