Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Rad27 (Fen-1) nuclease inhibits Ty1 mobility in Saccharomyces cerevisiae.

Genetics - 1 Jan 2003

Sundararajan Anuradha, Lee Bum-Soo, Garfinkel David J

Abstract excerpt

Although most Ty1 elements in Saccharomyces cerevisiae are competent for retrotransposition, host defense genes can inhibit different steps of the Ty1 life cycle. Here, we demonstrate that Rad27, a structure-specific nuclease that plays an important role in DNA replication and genome stability, inhibits Ty1 at a post-translational level. We have examined the effects of various rad27 mutations on Ty1 element...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endodeoxyribonucleases
Share to Flap Endonucleases
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Recombination, Genetic

Share to Retroelements

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12586696
DOI: 10.1093/genetics/163.1.55
PMCID: PMC1462422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Rad27 (Fen-1) nuclease inhibits Ty1 mobility in Saccharomyces cerevisiae.PMID 12586696Read ↗

Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance.Semantic proximity Read ↗

S-phase checkpoint pathways stimulate the mobility of the retrovirus-like transposon Ty1.Semantic proximity Read ↗

The yeast retrotransposons Ty1 and Ty3 require the RNA Lariat debranching enzyme, Dbr1p, for efficient accumulation of reverse transcripts.Semantic proximity Read ↗

Evolution of Ty1 copy number control in yeast by horizontal transfer of a <i>gag</i> geneSemantic proximity Read ↗

Nucleotide excision repair/TFIIH helicases RAD3 and SSL2 inhibit short-sequence recombination and Ty1 retrotransposition by similar mechanisms.Semantic proximity Read ↗

Heterogeneous functional Ty1 elements are abundant in the Saccharomyces cerevisiae genome.Semantic proximity Read ↗

Roles for the Rad27 Flap Endonuclease in Mitochondrial Mutagenesis and Double-Strand Break Repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

RNA branching and debranching in the yeast retrovirus-like element Ty1.Semantic proximity Read ↗

Novel function of Rad27 (FEN-1) in restricting short-sequence recombination.Semantic proximity Read ↗

A genetic and structural study of genome rearrangements mediated by high copy repeat Ty1 elements.Semantic proximity Read ↗

Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability.Semantic proximity Read ↗

Relationship between RNA lariat debranching and Ty1 element retrotransposition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.