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Article

Nucleotide excision repair/TFIIH helicases RAD3 and SSL2 inhibit short-sequence recombination and Ty1 retrotransposition by similar mechanisms.

Molecular and cellular biology - 1 Apr 2000

Lee B S, Bi L, Garfinkel D J, Bailis A M

Abstract excerpt

Eukaryotic genomes contain potentially unstable sequences whose rearrangement threatens genome structure and function. Here we show that certain mutant alleles of the nucleotide excision repair (NER)/TFIIH helicase genes RAD3 and SSL2 (RAD25) confer synthetic lethality and destabilize the Saccharomyces cerevisiae genome by increasing both short-sequence recombination and Ty1 retrotransposition. The rad3-G595R and...

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Source

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Identifiers

PMID: 10713167
DOI: 10.1128/MCB.20.7.2436-2445.2000
PMCID: PMC85430

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Nucleotide excision repair/TFIIH helicases RAD3 and SSL2 inhibit short-sequence recombination and Ty1 retrotransposition by similar mechanisms.PMID 10713167Read ↗

Posttranslational inhibition of Ty1 retrotransposition by nucleotide excision repair/transcription factor TFIIH subunits Ssl2p and Rad3p.Semantic proximity Read ↗

The essential helicase gene RAD3 suppresses short-sequence recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

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