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Article

Relationship between RNA lariat debranching and Ty1 element retrotransposition.

Journal of virology - 1 Dec 2003

Salem Laura A, Boucher Christopher L, Menees Thomas M

Abstract excerpt

The Saccharomyces cerevisiae DBR1 gene encodes a 2'-5' phosphodiesterase that debranches intron RNA lariats following splicing. Yeast dbr1 mutants accumulate intron lariats and are also defective for mobility of the retrotransposons Ty1 and Ty3. We used a mutagenic PCR method to generate a collection of dbr1 mutant alleles to explore the relationship between the roles of DBR1 in transposition and debranching....

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Source

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Identifiers

PMID: 14610201
DOI: 10.1128/jvi.77.23.12795-12806.2003
PMCID: PMC262579

Genes

DBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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