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Article

Specific homeodomain-DNA interactions are required for HOX11-mediated transformation.

Blood - 15 Jun 2003

Owens Bronwyn M, Zhu Yuan-Xiao, Suen Ting-Chung, Wang Pei-Xiang, Greenblatt Jack F, Goss Paul E, Hawley Robert G

Abstract excerpt

HOX11 encodes a homeodomain protein that is aberrantly expressed in T-cell acute lymphoblastic leukemia as a consequence of the t(10;14) and t(7;10) chromosomal translocations. We previously reported that HOX11 immortalizes murine hematopoietic progenitors and induces pre-T-cell tumors in mice after long latency. It has been demonstrated in a number of studies that HOX11, similar to other homeodomain proteins,...

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Identifiers

PMID: 12586625
DOI: 10.1182/blood-2002-09-2857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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