Article
Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system.
Biological psychiatry - 15 Feb 2003
Ralph-Williams Rebecca J, Paulus Martin P, Zhuang Xiaoxi, Hen Rene, Geyer Mark A
Abstract excerpt
BACKGROUND: Dopamine transporter (DAT) knockdown (KD) mice, with approximately 90% loss of expression of the DAT, allow for the examination of the behavioral consequences of a chronically dysregulated dopamine system. The DAT KD mice have hyperdopaminergic tone, are hyperactive, and show impaired response inhibition in a number of paradigms. We hypothesized that the DAT KD mice would also display deficits in...
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