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Article

In vitro and in vivo characterization of a murine cytomegalovirus with a mutation at open reading frame m166.

Journal of virology - 1 Mar 2003

Zhu Jiaming, Chen Jennifer, Hai Rong, Tong Tuong, Xiao Jianqiao, Zhan Xiaoyan, Lu Sangwei, Liu Fenyong

Abstract excerpt

We have recently generated a pool of murine cytomegalovirus (MCMV) mutants by using a Tn3-based transposon mutagenesis approach. In this study, one of the mutants, Rvm166, which contained the transposon sequence at open reading frame m166, was characterized both in tissue culture and in immunocompetent BALB/c mice and immunodeficient SCID mice. The viral mutant replicated as well as the wild-type Smith strain in...

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Identifiers

PMID: 12584312
DOI: 10.1128/jvi.77.5.2882-2891.2003
PMCID: PMC149767

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