Article
Murine cytomegalovirus with a transposon insertional mutation at open reading frame m155 is deficient in growth and virulence in mice.
Journal of virology - 1 Jul 2004
Abenes Gerardo, Chan Karen, Lee Manfred, Haghjoo Erik, Zhu Jiaming, Zhou Tianhong, Zhan Xiaoyan, Liu Fenyong
Abstract excerpt
A pool of murine cytomegalovirus (MCMV) mutants was previously generated by using a Tn3-based transposon mutagenesis approach (X. Zhan, M. Lee, J. Xiao, and F. Liu, J. Virol. 74:7411-7421, 2000). In this study, one of the MCMV mutants, Rvm155, which contained the transposon insertion in open reading frame m155, was characterized in vitro for its replication in tissue culture and in vivo for its growth and...
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