Article
NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan.
Diseases of the colon and rectum - 1 Jul 2007
Huang Chi-Chou, Chien Wen-Pin, Wong Ruey-Hong, Cheng Ya-Wen, Chen Meng-Cheng, Chou Ming-Chih, Lee Huei
Abstract excerpt
In Taiwan, colorectal cancer has one of the highest rates of increased incidence in the past two decades. Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence. Thus, the NAT2 fast acetylator genotype may be associated with colorectal cancer risk. However, the association between the NAT2 genotype and...
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