Article
Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines?
Cancer causes & control : CCC - 1 Aug 2008
Lumbreras B, Garte S, Overvad K, Tjonneland A, Clavel-Chapelon F, Linseisen J P, Boeing H, Trichopoulou A, Palli D, Peluso M, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita H B, Peeters P H, Lund E, Martinez C, Dorronsoro M, Barricarte A, Chirlaque M-D, Quiros J R, Berglund G, Hallmans G, Day N E, Key T J, Saracci R, Kaaks R, Malaveille C, Ferrari P, Boffetta P, Norat T, Riboli E, Gonzalez C A, Vineis P
Abstract excerpt
BACKGROUND: The suspect carcinogens, heterocyclic amines (HAAs), found in well-done meat require host-mediated metabolic activation before inducing DNA mutations. The role of SULT1A1 and of NAT2 on the activation of HAAs suggests that NAT2 rapid acetylator genotype and SULT1A1 allele variants can have an effect on HAA carcinogenicity. METHODS: Data were collected as part of a case-control study nested within the...
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