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Article

Chemokine receptor genotype and response to interleukin-2 therapy in HIV-1-infected individuals.

Clinical immunology (Orlando, Fla.) - 1 Jan 2003

Clegg Alison, Williamson Peter, Biti Robyn, Cooper David, Emery Sean, Carr Andrew, Stewart Graeme

Abstract excerpt

Interleukin-2 therapy is an immune-based treatment for HIV-1-infected individuals with declining CD4(+) T cell counts. Intravenous IL-2 produces an elevation of circulating CD4(+) T cells, but with a varying degree of effectiveness in individual patients. IL-2 is also known to increase the expression of chemokine receptors, coreceptors for HIV-1. Allelic variation in chemokine receptor genes can markedly affect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12584049
DOI: 10.1016/s1521-6616(02)00020-7

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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