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Article

Identification of the genecluster involved in muraymycin biosynthesis from <i>Streptomyces</i> sp. NRRL 30471

23 Dec 2010

Abstract excerpt

Muraymycin, a potent translocase I inhibitor with clinical potential, is produced by Streptomyces sp. NRRL 30471. The structure of muraymycin is highly unusual and contains the hexahydro-2-imino-4-pyrimidylglycyl moiety (epicapreomycidine) and an ureido bond. Here we report the identification of the muraymycin gene cluster from Streptomyces sp. NRRL 30471. Sequencing analysis of a 43.4-kb contiguous region...

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PMID: 21180767
DOI: 10.1039/c0mb00237b

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