Article
A single-nucleotide natural variation (U4 to C4) in an influenza A virus promoter exhibits a large structural change: implications for differential viral RNA synthesis by RNA-dependent RNA polymerase.
Nucleic acids research - 15 Feb 2003
Lee Mi-Kyung, Bae Sung-Hun, Park Chin-Ju, Cheong Hae-Kap, Cheong Chaejoon, Choi Byong-Seok
Abstract excerpt
The influenza A virus promoter is recognized by the influenza A virus RNA-dependent RNA polymerase, and directs both transcription and replication of the viral RNA genome. Within the sequence of this promoter, flu strains exhibit a natural, unique variation, either a U or a C, at the fourth position from the 3' end. Promoters that contain a C residue (C4 promoter), which are invariably found in genome segments...
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