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Article

Influenza virus genome C4 promoter/origin attenuates its transcription and replication activity by the low polymerase recognition activity.

Virology - 20 Dec 2010

Jiang Hongbing, Zhang Shijian, Wang Qiang, Wang Jinlan, Geng Liqing, Toyoda Tetsuya

Abstract excerpt

A natural variation is observed at position 4 of the 3'-end of influenza A virus genomes, where U (U4) or C (C4) is present. The replicon activity of C4 was 28% of U4. We compared the transcription and replication activity of U4 [v84(U4)], C4 [v84(C4)] and the complimentary RNA (c84) using the purified influenza virus RNA polymerase in vitro. ApG-primed replication activities of v84(C4) and c84 were 23.8% and...

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PMID: 20956010
DOI: 10.1016/j.virol.2010.09.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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