Article
Cdc42p GTPase regulates the budded-to-hyphal-form transition and expression of hypha-specific transcripts in Candida albicans.
Eukaryotic cell - 1 Jun 2004
VandenBerg Alysia L, Ibrahim Ashraf S, Edwards John E, Toenjes Kurt A, Johnson Douglas I
Abstract excerpt
The yeast Candida albicans is a major opportunistic pathogen of immunocompromised individuals. It can grow in several distinct morphological states, including budded and hyphal forms, and the ability to make the dynamic transition between these forms is strongly correlated with virulence. Recent studies implicating the Cdc42p GTPase in hypha formation relied on cdc42 mutations that affected the mitotic functions...
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