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Article

Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.

Blood - 15 Feb 2007

Volkheimer Alicia D, Weinberg J Brice, Beasley Bethany E, Whitesides John F, Gockerman Jon P, Moore Joseph O, Kelsoe Garnett, Goodman Barbara K, Levesque Marc C

Abstract excerpt

Somatic mutations of immunoglobulin genes characterize mature memory B cells, and intraclonal B-cell diversification is typically associated with expansion of B-cell clones with greater affinity for antigen (antigen drive). Evidence for a role of antigen in progression of intraclonal chronic lymphocytic leukemia (CLL) cell diversification in patients with mutated immunoglobulin genes has not been previously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17082314
DOI: 10.1182/blood-2006-05-020644
PMCID: PMC1794047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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