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Article

Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study.

The Journal of urology - 1 Mar 2003

Sperling Herbert, Eisenhardt Andreas, Virchow Sebastian, Hauck Ekkehard, Lenk Severin, Porst Hartmut, Stief Christain, Wetterauer Ulrich, Rubben Herbert, Muller Norbert, Siffert Winfried

Abstract excerpt

PURPOSE: Sildenafil is the oral phosphodiesterase-5 inhibitor that revolutionized treatment for erectile dysfunction. We investigated a potential association of the G protein beta 3 subunit (GNB3) C825T polymorphism, a determinant of intracellular signal transduction, with the drug response to sildenafil in patients with erectile dysfunction. MATERIALS AND METHODS: In 113 men with erectile dysfunction and 111...

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Identifiers

PMID: 12576843
DOI: 10.1097/01.ju.0000058369.72348.ba

Genes

GNB3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study.PMID 12576843Read ↗

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PDE5A Polymorphisms Influence on Sildenafil Treatment SuccessSemantic proximity Read ↗

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