Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism of the G protein β3 subunit gene influences the efficacy of sildenafil in patients with pulmonary hypertension.

Internal medicine (Tokyo, Japan) - 1 Jan 2014

Sekine Ayumi, Tanabe Nobuhiro, Sugiura Toshihiko, Shigeta Ayako, Jujo Takayuki, Nishimura Rintaro, Sakao Seiichiro, Kasahara Yasunori, Tatsumi Koichiro

Abstract excerpt

OBJECTIVE: The C825T polymorphism in the G protein β3 subunit gene (GNB3) influences the efficacy of sildenafil in patients with erectile dysfunction. The effects of this polymorphism on the therapeutic response to sildenafil in patients with pulmonary hypertension remains unknown. To investigate whether the GNB3C825T polymorphism is associated with the clinical efficacy of sildenafil in patients with pulmonary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Heterotrimeric GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

Share to Piperazines

Share to Purines

Share to Sulfones

Share to Treatment Outcome

Share to Vasodilation

Source

Identifiers

PMID: 24531084
DOI: 10.2169/internalmedicine.53.0658

Genes

GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism of the G protein β3 subunit gene influences the efficacy of sildenafil in patients with pulmonary hypertension.PMID 24531084Read ↗

RETRACTED: G-protein β3 subunit gene 825C/T polymorphism and its association with the presence, severity, and duration of vasculogenic erectile dysfunctionSemantic proximity Read ↗

Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study.Semantic proximity Read ↗

The C825T polymorphism of the G-protein β3 subunit gene and its association with hypertension and stroke: an updated meta-analysis.Semantic proximity Read ↗

G protein beta3 subunit gene 825T allele is associated with increased left ventricular mass in young subjects with mild hypertension.Semantic proximity Read ↗

825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension.Semantic proximity Read ↗

The genetic variant C825T of the beta 3 subunit of G protein is associated with hypertension in a Portuguese population.Semantic proximity Read ↗

G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk: An Updated Review.Semantic proximity Read ↗

Association between a polymorphism in the G protein β3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarctionSemantic proximity Read ↗

Association of C825T polymorphism of G protein beta3 subunit with the autonomic nervous system in young healthy Japanese individuals.Semantic proximity Read ↗

Influence of G-protein β-Polypeptide 3 C825T Polymorphism on Antihypertensive Response to Telmisartan and Amlodipine in Chinese Patients.Semantic proximity Read ↗

G-Protein beta(3) subunit gene variant and left ventricular hypertrophy in essential hypertension.Semantic proximity Read ↗

G-protein beta3 subunit variant C825T is a risk factor for hypertension in Japanese females--a prospective cohort study over 5 years.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.