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Article

Examining the role of glutamic acid 183 in chloroperoxidase catalysis.

The Journal of biological chemistry - 18 Apr 2003

Yi Xianwen, Conesa Ana, Punt Peter J, Hager Lowell P

Abstract excerpt

Site-directed mutagenesis has been used to investigate the role of glutamic acid 183 in chloroperoxidase catalysis. Based on the x-ray crystallographic structure of chloroperoxidase, Glu-183 is postulated to function on distal side of the heme prosthetic group as an acid-base catalyst in facilitating the reaction between the peroxidase and hydrogen peroxide with the formation of Compound I. In contrast, the other...

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PMID: 12576477
DOI: 10.1074/jbc.M210906200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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