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Article

Genetic dissection of the phospholipid hydroperoxidase activity of yeast gpx3 reveals its functional importance.

The Journal of biological chemistry - 5 Nov 2004

Avery Angela M, Willetts Sylvia A, Avery Simon V

Abstract excerpt

Saccharomyces cerevisiae expresses multiple phospholipid hydroperoxide glutathione peroxidase (PHGPx)-like proteins in the absence of a classical glutathione peroxidase (cGPx), providing a unique system for dissecting the roles of these enzymes in vivo. The Gpx3 (Orp1/PHGpx3) protein transduces the hydroperoxide signal to the transcription factor Yap1, a function that could account for most GPX-dependent...

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PMID: 15337745
DOI: 10.1074/jbc.M408340200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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