Article
Mutations affecting the calcium-binding site of myeloperoxidase and lactoperoxidase.
Biochemical and biophysical research communications - 9 Mar 2001
Shin K, Hayasawa H, Lönnerdal B
Abstract excerpt
Both myeloperoxidase (MPO) and lactoperoxidase (LPO) contain high affinity bound calcium, which has been suggested to play a structural role. Asp-96 in MPO, a residue next to the histidine distal from the heme prosthetic group, has been assigned to the calcium-binding site of the enzyme by X-ray crystallography. Multiple sequence alignment of known animal peroxidases has revealed that the calcium-binding site is...
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