Article
Infantile spasms and Down syndrome: a new animal model.
Pediatric research - 1 May 2009
Cortez Miguel A, Shen Liqing, Wu Ying, Aleem Ilyas S, Trepanier Catherine H, Sadeghnia Hamid R, Ashraf Asim, Kanawaty Ashlin, Liu Chen-Chu, Stewart Lee, Snead O Carter
Abstract excerpt
Infantile spasms is a catastrophic childhood seizure disorder for which few animal models exist. Children with Down syndrome are highly susceptible to infantile spasms. The Ts65Dn mouse is a valid model for Down syndrome; therefore, we tested the hypothesis that the Ts65Dn mouse represents a substrate for an animal model of infantile spasms. The baseline of naïve Ts65Dn mice showed spontaneous spike-and-wave...
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