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Article

Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain.

Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 2003

Storm Elaine E, Rubenstein John L R, Martin Gail R

Abstract excerpt

FGF8 is known to be an important regulator of forebrain development. Here, we investigated the effects of varying the level of Fgf8 expression in the mouse forebrain. We detected two distinct responses, one that was proportionate with Fgf8 expression and another that was not. The latter response, which led to effects on cell survival, displayed a paradoxical relationship to Fgf8 dosage. Either eliminating or...

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Identifiers

PMID: 12574514
DOI: 10.1073/pnas.0337736100
PMCID: PMC149906

Genes

FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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