Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development.

Developmental biology - 1 Aug 2008

Okada Toshiaki, Okumura Yuki, Motoyama Jun, Ogawa Masaharu

Abstract excerpt

FGF8 has been reported to act as a primary regulator of neocortical patterning along the anteroposterior (AP) axis in the mouse telencephalon, and disruption of FGF signaling causes distortion of molecular arealization along the AP axis. Since hypoplasia of midline structures is observed in Fgf8 mutant mice, FGF8 is also postulated to be involved in telencephalic midline development. In this study we analyzed the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibroblast Growth Factor 8
Share to Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to LIM-Homeodomain Proteins

Share to Mice, Inbred ICR

Share to Telencephalon

Share to Thyroid Nuclear Factor 1

Share to Zinc Finger Protein Gli3

Source

Identifiers

PMID: 18547559
DOI: 10.1016/j.ydbio.2008.04.034

Genes

FGF8
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development.PMID 18547559Read ↗

FGF signaling through FGFR1 is required for olfactory bulb morphogenesis.Semantic proximity Read ↗

FGF signaling is required for brain left-right asymmetry and brain midline formation.Semantic proximity Read ↗

Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum.Semantic proximity Read ↗

A function for Egf receptor signaling in expanding the developing brain in Drosophila.Semantic proximity Read ↗

The jing and ras1 pathways are functionally related during CNS midline and tracheal development.Semantic proximity Read ↗

Zebrafish Rfx4 controls dorsal and ventral midline formation in the neural tubeSemantic proximity Read ↗

Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton.Semantic proximity Read ↗

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers.Semantic proximity Read ↗

Midline Fasciclin: a Drosophila Fasciclin-I-related membrane protein localized to the CNS midline cells and trachea.Semantic proximity Read ↗

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres.Semantic proximity Read ↗

Regulation of midline development by antagonism of lefty and nodal signaling.Semantic proximity Read ↗

Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.