Article
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers.
Development (Cambridge, England) - 1 May 2006
Storm Elaine E, Garel Sonia, Borello Ugo, Hebert Jean M, Martinez Salvador, McConnell Susan K, Martin Gail R, Rubenstein John L R
Abstract excerpt
Mouse embryos bearing hypomorphic and conditional null Fgf8 mutations have small and abnormally patterned telencephalons. We provide evidence that the hypoplasia results from decreased Foxg1 expression, reduced cell proliferation and increased cell death. In addition, alterations in the expression of Bmp4, Wnt8b, Nkx2.1 and Shh are associated with abnormal development of dorsal and ventral structures....
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