Article
Apoptosis in mouse embryos: elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 1998
Manova K, Tomihara-Newberger C, Wang S, Godelman A, Kalantry S, Witty-Blease K, De Leon V, Chen W S, Lacy E, Bachvarova R F
Abstract excerpt
The pattern of apoptotic cell death has been surveyed in prestreak and primitive streak embryos of four strains of mice and in three mutants affecting gastrulation. In C57BL/6 embryos, a high level of cell death occurs in the early egg cylinder stage at embryonic day 5 (E5) to E5.5. In all strains, cell death is elevated shortly before gastrulation, but the level varies four- to fivefold among strains. During...
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