Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.

Genes & development - 15 Jan 2006

Fujitani Yoshio, Fujitani Shuko, Boyer Daniel F, Gannon Maureen, Kawaguchi Yoshiya, Ray Michael, Shiota Masakazu, Stein Roland W, Magnuson Mark A, Wright Christopher V E

Abstract excerpt

Pdx1 (IPF-1 in humans, which is altered in MODY-4) is essential for pancreas development and mature beta-cell function. Pdx1 is expressed dynamically within the developing foregut, but how its expression characteristics are linked to the various steps of organ specification, differentiation, and function is unknown. Deletion of a conserved enhancer region (Area I-II-III) from Pdx1 produced a hypomorphic allele...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Conserved Sequence
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Intestinal Mucosa

Share to Organogenesis

Share to Pancreas

Share to Regulatory Sequences, Nucleic Acid

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 16418487
DOI: 10.1101/gad.1360106
PMCID: PMC1356115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.PMID 16418487Read ↗

Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression.Semantic proximity Read ↗

Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.Semantic proximity Read ↗

Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.Semantic proximity Read ↗

Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.Semantic proximity Read ↗

Reduction of <i>Ptf1a</i> Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in MiceSemantic proximity Read ↗

Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood.Semantic proximity Read ↗

Transcription Factors in Islet Development and Physiology: Role of PDX‐1 in Beta‐Cell FunctionSemantic proximity Read ↗

PDX1 directs a core developmentally and evolutionarily conserved gene program in the pancreatic isletSemantic proximity Read ↗

Pdx1 regulates pancreas tubulogenesis and E-cadherin expressionSemantic proximity Read ↗

Developmental Expression of the Homeodomain Protein IDX-1 in Mice Transgenic for an IDX-1 Promoter/lacZ Transcriptional Reporter1Semantic proximity Read ↗

Insulin-promoter-factor 1 is required for pancreas development in mice.Semantic proximity Read ↗

Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.