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Article

Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma.

International journal of cancer - 10 Apr 2003

Byun Do-Sun, Cho Kyucheol, Ryu Byung-Kyu, Lee Min-Goo, Park Jae-Il, Chae Kwon-Seok, Kim Hyo-Jong, Chi Sung-Gil

Abstract excerpt

Mutational alterations of PTEN and PIK3CA, which negatively and positively regulate PI3-kinase activity, respectively, have been observed in many types of human cancer. To explore the implication of PTEN and PIK3CA mutations in gastric tumorigenesis, we characterized the expression and mutation status of the genes in 126 gastric tissues and 15 cell lines. Expression of PTEN transcript was abnormally low in 5 of...

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Identifiers

PMID: 12569555
DOI: 10.1002/ijc.10962

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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